Pirates beat Revenue Authority of Uganda in the previous round, 4-3 on aggregate. Mounana knocked out Power Dynamos of Zambia by a similiar aggregate score. The first legs will be played from April 17-19, with the return legs scheduled for May 1-3.

CAF Confederation Cup Last 16 draw

Onze Createurs (MLI) v ASEC Mimosas (CIV)

Djoliba (MLI) v Hearts of Oak (GHA)

ASO Chlef (ALG) v Club Africain (TUN)

Warri Wolves (NGR) v MK Etancheite (COD)

Zamalek (EGY) v FUS Rabat (MAR)

Mounana (GAB) v Orlando Pirates (RSA)

Young Africans (TAN) v Etoile Sahel (TUN)

Royal Leopard (SWZ) v V Club (COD)